https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31060 14 days) exposure to a PDA were compared to control infants without a PDA. Results: Thirty out of 189 infants had prolonged exposure to a PDA. The left heart remodeled to a larger and more spherical shape and thus significantly increased in volume. Most changes occurred in the first 4 weeks, plateaued, and then returned to control values. Systolic function and estimates of filling pressure increased and effective arterial elastance reduced with a PDA, however contractility was unchanged. Wall thickness increased after 4 weeks of increased volume exposure. Conclusion: The preterm PDA induces early and significant remodeling of the left heart. A compensated cardiac physiology was seen with preserved systolic function, suggesting adaptive rather than pathological remodeling changes with prolonged exposure to a PDA.]]> Wed 10 Nov 2021 15:14:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26058 Wed 09 Mar 2022 16:04:46 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44306 Tue 11 Oct 2022 15:59:20 AEDT ]]>